Table of Contents
- What is Rybelsus (semaglutide)? Benefits, Risks, And Side effects?
- So what is Rybelsus (semaglutide)?
What is Rybelsus (semaglutide)? Benefits, Risks, And Side effects?
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Indication of Rybelsus (semaglutide):
Limitations of Rybelsus (semaglutide)
Rybelsus ( oral semaglutide) of course has some limitations. Do not use Rybelsus if you have a history of pancreatitis, a family history of medullary thyroid cancer, or pancreatic cancer. Studies on rats showed some of the signs of medullary thyroid cancer and pancreatic cancer. There is not enough data to prove any harm to humans. This is possible because the genetics of human beings are different. The dosing and exposure are very different as well.
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Pros of Rybelsus (semaglutide)
Good news for patients with kidney and liver problems
Weight loss associated with Rybelsus
Rybelsus causes significant weight loss almost as much as or more than Victoza. This medication reduces appetite. It also slows down the stomach emptying and makes you feel full for a long time.
Cons or Side effects of Rybelsus (oral semaglutide)
There is a major disadvantage of this medication. You must take it at least 30 minutes before any food or beverage. Also, you can take it only with only 4 ounces of water but nothing else. Also, you should wait another 30 minutes before you eat or drink anything else.
Stomach and intestinal issues
Rybelsus (semaglutide) is expensive.
Rybelsus itself may not be enough
If you have uncontrolled blood sugars you may need more than rybelsus. Sometimes you need a drug that works immediately. Rybelsus may not start working until 4 weeks. For example, if your blood sugars are running more than 200 you may need extra meds. Your physician may want to use medications that are effective faster than Rybelsus. Sometimes you may go on a combination regimen that includes Rybelsus. But, taking Rybelsus on its own may not completely bring you to the goal. That is because the titration schedule takes a few months to reach the desired dosage.
Dosing information
- The starting dose is 3 mg every day in the morning. After a month the dose can be increased to 7 mg. After another month if needed the dose can be increased to 14 mg daily. Not every patient will need or be able to tolerate a 14 mg dose.
- In case of overdose, patients may have severe prolonged vomiting. Other neurological side effects such as confusion and severe headache may occur. Dehydration may happen. Doctors should observe hospitalized patients and give appropriate care for dehydrated patients. Physicians should remember that the half-life of Rybelsus is 1 week.
Caution: Rybelsus is not recommended for pregnant and breastfeeding women.
Ask one of our diabetes specialists about prescription and dosing after a formal consultation.
How to store Rybelsus
Room temperature between 68°F and 77°F (20°C to 25°C).
Keep in a dry place away from moisture.
Store the tablet in the original pack/bottle.
Keep the tablet in the pack until you are ready to take it.
If you need further information please ask our endocrinologist/diabetes specialist about Rybelsus storage.
What happens if I miss a rybelsus dose
Skip the missed dose and continue taking your medication the next day.
Finally, never try to crash the rybelsus tablets.
My experience as an Endocrinologist with Rybelsus (semaglutide)
In our diabetes care center, I see a lot of patients with uncontrolled diabetes. I started prescribing Rybelsus (oral semaglutide) around mid-October 2019. We always ask my patients how they feel, the side effects, and perceived benefits. Our team finds out how blood sugar control is on a day-to-day basis. Although a lot of studies are done and the drug has proven itself, personal experience is invaluable. If you cant take Rybelsus, consider using the highly effective SugarMD Advanced Glucose Support Supplement. You will be amazed by the results with no side effects.
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So far, my experience has been positive if they can obtain the medication. I sometimes make personal phone calls to the pharmacist for them to understand the voucher. This helps patients to obtain the medication at a very minimal cost. I hate when patients pay too many out-of-pocket costs. Nevertheless, patients did not report excessive side effects. Thankfully, the starting dose is small, and gradually increasing the dose allows the body to adapt.
Appetite Reduction with Rybelsus
Patients also report a significant reduction in their appetite. Even with the low dose, blood sugar control improves which was surprising for me. I was expecting blood sugar to improve not until 7 to 14 mg. The truth the fact is that everybody will have different sensitivity and responses to Rybelsus. Somebody may respond to 3 mg greatly. On the other hand, another patient may not respond to even 14 mg if they are totally resistant to these agents.
The Role of an Endocrinologist and/or Diabetes Specialist
As an endocrinologist, my job is to determine which patient will respond best to any medication for diabetes.
Treating diabetes is a combination of art and science. Just like one dress may not fit all, Rybelsus treatment may help one patient but not help another. That is why asking the opinion of an endocrinologist or diabetes specialist will make a great difference. With a few small changes in the diabetes treatment regimen, a lot can change.
An endocrinologist who has a special interest in diabetes care management will be able to understand your problems and challenges. He or she will be able to give you the best medications. They will choose the necessary meds that can fit you. Most importantly, a diabetes doctor along with the help of personal diabetes coaches helps you with your lifestyle changes in order to avoid medications.
Author: Ahmet Ergin, MD, FACE, CDCES, ECNU
About the author:
Dr. Ahmet Ergin is the author of The Ultimate Diabetes Book and the Founder of the SugarMD youtube channel. He practices in Port Saint Lucie, FL as an endocrinologist physician.