Side Effects of Metformin: Less Known Issues

side effects of metformin

Surprising But Dangerous Side Effects of Metformin


Metformin is the most commonly used diabetic medication and yet the most debated diabetes medication as well. There are many metformin side effects, which is why it’s important to be fully aware of what they are before you start taking this medication. In this blog post, we will discuss all of the possible side effects of metformin and how to deal with them. We will also provide information on how to safely take this medication and get the most out of it.

Common Side effects of Metformin

Metformin is a great medication for managing diabetes. The most common side effects include but are not limited to heartburn, stomach pain, and nausea or vomiting to name just three! It can also cause gas/bloating; diarrhea; weight loss (sometimes); headache. There are other less intense but still prevalent ones such as taste changes from metallic substances in one’s mouth.


More serious side effects include low blood sugar, lactic acidosis, and vitamin B12 deficiency. Metformin should be used with caution in people with kidney or liver disease, as well as in those at risk for heart disease.


Let’s go over more in-depth about some of the metformin side effects:

Diarrhea- A Common Metformin Side Effect

Diarrhea and metformin
Diarrhea and metformin

Many patients cannot take the right amount of metformin because of its bad effects on their stomachs. These stomach problems include diarrhea, nausea, flatulence, indigestion, vomiting, and abdominal discomfort. Diarrhea and nausea are the most common problems.

Even though starting at a low dose and slowly increasing the dose may help prevent some of the side effects associated with metformin, some patients are still not able to tolerate it. It can be difficult to convince patients to start taking metformin again if they have had bad side effects in the past. However, this is an important drug for treating diabetes. On the other hand, Dr. Ergin says he successfully used Super Berberine in patients who did not want to take metformin.

How to Stop Diarrhea Induced by Metformin

There are ways to lower the side effects of metformin. Appropriate titration of immediate-release metformin can help. Also, using extended-release metformin or delayed-release metformin can help. Additionally, taking gut microbiome modulators or alternative pharmacological or herbal therapies such as berberine or dihydroberberine when metformin cannot be tolerated can also help.

Less Known Side Effects Of Metformin

Excessive Tiredness

Metformin is a medication that can sometimes cause extreme tiredness. If you’re taking metformin and find yourself constantly exhausted, it’s important to speak to your doctor about alternative treatments or herbal diabetes remedies.

Heart Rhythm Problems

Some people who take the diabetes medication metformin experience an increase in lactic acid in their blood. This can lead to heart problems, including a low heart rate or a high heart rate that can feel like palpitations. On the other hand, metformin is associated with a lower risk of atrial fibrillation and ventricular arrhythmias when compared to sulfonylureas.

Lactic acidosis

Some people who take Metformin may experience a serious condition called lactic acidosis. This condition can cause the following symptoms: feeling dizzy or lightheaded, severe drowsiness, muscle pain, tiredness, feeling cold or blue in the skin, fast/difficult breathing, slow/irregular heartbeat, stomach pain with diarrhea, nausea or vomiting.

Low Blood Sugar

Usually, metformin does not cause low blood sugar. However, if you take this drug with other anti-diabetic drugs, there is a greater chance that you will experience low blood sugar. This can happen especially if you do a lot of exercises, drink a lot of alcohol, or don’t eat enough food.

Metformin Allergy

Allergic reactions to this drug are rare; however, this product may contain some allergens that could cause a reaction in some people. If you have any allergies, be sure to check the ingredients list before taking this medication.

B12 Deficiency- A long term side effect of metformin

Metformin can reduce the amount of vitamin B12 in your body. This could lead to anemia or low red blood cell counts, so it’s important that you get enough through diet alone if possible and talk with a doctor before stopping metformin altogether! SugarMD Neuropathy Support will ensure you never develop B12 deficiency or neuropathy due to metformin or diabetes. If you think you may have anemia, make an appointment with your doctor to get your red blood cell levels checked. Anemia is a condition where you have low levels of red blood cells. This can cause tiredness, dizziness, and lightheadedness. To learn more about B12 deficiency and diabetes click here. 


Can You Take Metformin If You Have Kidney Disease?

If you have mild or moderate kidney problems, your doctor may start with a lower dosage of metformin. If severe conditions are present such as aging and/or age 80 years old or more, then this drug may not be safe for use in these individuals due to potential risks from lactic acidosis.

Can Someone with Heart Disease Take Metformin?

If you have heart failure or have recently had a heart attack, it’s important to be aware of the risks associated with taking metformin. This medication can prevent your kidneys from removing metformin from your body as effectively as they normally would, raising your risk of lactic acidosis. So if you’re having any problems with your heart, it’s best to avoid taking metformin altogether.

Can Someone With Liver Disease Take Metformin?

Taking metformin if you have severe liver problems is dangerous. Your liver clears lactic acid from your body, and if you have severe liver problems, there could be a buildup of lactic acid. This would raise your risk of lactic acidosis. Metformin also raises your risk, so taking it if you have liver problems is not a good idea.

Want to learn everything about Metformin? Click Here. 

Can Drink Alcohol Raise Risk of Side Effects With Metformin?

Metformin and alcohol don’t mix well. drinking too much can lead to hypoglycemia or low blood sugar levels due to the increased risk for this with metformin use; also you’re at higher risk of developing lactic acidosis because it causes an increase in bodily production/release rate of naturally occurring acids such as hydrogen citrate which is found mostly muscles (away from organs). So while yes – socializing during happy hour might be fun initially but long term may cause problems. To learn more click here. 

Should I stop taking metformin before surgery or procedure?

Stop taking metformin before surgery or a radiology procedure that uses iodine contrast. This can slow the removal of this drug from your body, raising risk for lactic acidosis and other side effects like kidney damage; talk with the doctor about timing on when to resume taking it after procedures are complete as well!

What is metformin used for?

Metformin is a medication typically used to treat type 2 diabetes. It helps to control blood sugar levels by reducing the amount of sugar produced by the liver and by increasing the body’s sensitivity to insulin. Metformin can also be used to treat polycystic ovary syndrome (PCOS) and pre-diabetes. In some cases, it may be used in combination with other medications. Metformin is generally well-tolerated, but it can cause side effects such as nausea, diarrhea, and headaches. It’s important to talk to your doctor about all the potential risks and benefits of metformin before starting treatment.

When to Take Metformin

Metformin (1000 mg) is often prescribed for people with type 2 diabetes. But when should you take it? According to the American Diabetes Association, the best time to take metformin is with meals. This helps to reduce the side effects of metformin, such as stomach upset. If you are taking metformin twice a day, it’s important to space the doses out so that they are evenly spaced throughout the day. For example, you could take one dose at breakfast and one dose at dinner. Speak to your doctor or pharmacist if you have any questions about when to take metformin 1000 mg.

What are metformin alternatives?

super berberine
Super Berberine Click To Purchase

If you’re looking for an alternative to metformin, dihydroberberine may be worth a try. This natural compound has been shown to improve insulin sensitivity and reduce blood sugar levels in diabetics. In one study, dihydroberberine was found to be as effective as metformin at lowering blood sugar levels. Additionally, dihydroberberine has fewer side effects than metformin, making it a safer option for those with diabetes. So if you’re looking for an effective and safe alternative to metformin, dihydroberberine may be worth a try.


What happens if you take metformin and you don’t need it.

Metformin is a biguanide, which means it works by decreasing the amount of sugar produced by the liver and the absorption of sugar in the intestine. In people with type 2 diabetes, metformin can help to improve blood sugar control. However, in people without diabetes, metformin may cause low blood sugar levels. Therefore, it’s important to monitor your blood sugar levels if you are taking metformin and don’t

Ahmet Ergin, MD, CDCES, FACE

Author of The Ultimate Diabetes Book

Founder of SugarMD Youtube Channel



Leave a Reply